Detección de mutaciones del gen EGFR en ADN circulante por medio de biopsia líquida en pacientes con cáncer pulmonar de células no pequeñas: Revisión rápida

Translated title of the contribution: Detection of EGFR gene mutations in circulating DNA by liquid biopsy in patients with non-small cell lung cancer: Brief review

Marina Janeth Egoavil Guerra, Virgilio E. Failoc-Rojas, Fradis Gil-Olivares, Rodrigo Motta-Guerrero, Eduardo Tomás Payet Meza, Gustavo Sarria Bardales, Karina Mayra Aliaga Llerena

Research output: Contribution to journalReview articlepeer-review

Abstract

Lung cancer is a public health problem due to its high morbidity and mortality worldwide and in Peru. In non-small cell lung cancer, the detection of mutations of the epidermal growth factor receptor (EGFR) has been useful for the choice of therapeutics for this disease. In the present article we aim to discuss current and relevant information on the best diagnostic technique for EGFR in patients with non-small cell lung cancer. The main cancer guidelines and two systematic reviews showed evidence in favor of the diagnosis of EGFR gene mutations on liquid biopsy as an alternative to tissue biopsy at the beginning of diagnosis and with a greater acceptance use, in the clinical setting of NSCLC patients with sensitive EGFR mutations. This healthcare technology may be useful in our country, and we propose its use in two clinical scenarios.

Translated title of the contributionDetection of EGFR gene mutations in circulating DNA by liquid biopsy in patients with non-small cell lung cancer: Brief review
Original languageSpanish
Pages (from-to)145-150
Number of pages6
JournalActa Medica Peruana
Volume38
Issue number2
DOIs
StatePublished - Jun 2021

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