COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study

Mario J. Valladares-Garrido, Sandra Zeña-ñañez, C. Ichiro Peralta, Jacqueline B. Puicón-Suárez, Cristian Díaz-Vélez, Virgilio E. Failoc-Rojas

Research output: Contribution to journalArticlepeer-review

Abstract

COVID-19 vaccines have achieved a significant reduction in mortality, yet objective es-timates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admis-sion, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28–0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.

Original languageEnglish
Article number812
JournalVaccines
Volume10
Issue number5
DOIs
StatePublished - May 2022

Keywords

  • COVID-19
  • mortality
  • Peru
  • vaccination
  • vaccine effectiveness

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