TY - JOUR
T1 - Brain perfusion during manic episode and at 6-month follow-up period in bipolar disorder patients: Correlation with cognitive functions
AU - Estudillo-Guerra, Maria Anayali
AU - Pacheco-Barrios, Kevin
AU - Cardenas-Rojas, Alejandra
AU - Adame-Ocampo, Gloria
AU - Camprodon, Joan A.
AU - Morales-Quezada, Leon
AU - Gutiérrez-Mora, Doris
AU - Flores-Ramos, Mónica
N1 - Funding Information:
This study was supported by the National Institute of Psychiatry ?Ram?n de la Fuente Mu?iz,? CDMX, M?xico. The authors thank to Dr. Hiroshi Matusuda, FUJIFILM Toyama Chemical Co. and Japanese Society of Nuclear Medicine as a project of AORIN (Asia Oceania Research Initiative Network) for providing the eZIS for the elaboration of figure in this paper, to Dr. Carlos Adrian Rodr?guez ?lvarez for his support with the collection of clinical data and we appreciate the support from Nancy Boudreau RN with the review and correction of the manuscript.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: Patterns of altered cerebral perfusion and cognitive dysfunction have been described in Bipolar Disorder (BD) acute episodes and euthymia. Knowledge of the relationship between cognitive function and perfusion in a manic state and status when followed up is still limited. Objective: To describe brain perfusion alterations and its relationship with cognitive impairment in patients with BD during manic episodes and after 6 months. Methods: Observational-prospective study in 10 type I BD adults during moderate-severe manic episodes. We assessed sociodemographic data and clinical variables as well as cognitive function through Screening for Cognitive Impairment in Psychiatry (SCIP-S). Finally, we performed a Brain Perfusion SPECT using a Tc99m-ethyl cysteine dimer. Results: During manic episodes, patients showed cognitive impairment with a mean SCIP-S score of 63.8 ± 17.16. This was positively correlated with perfusion measured as relative reuptake index (RRI) at the right temporal pole (ρ = 0.65 p =.0435) and negatively correlated with right the orbitofrontal cortex (ρ = −0.70 p =.0077) and the right subgenual cingulate cortex (ρ = −0.70 p =.0256). Episode severity measured by the Young Mania Rating Scale (YMRS) positively correlated with RRI at the right temporal pole (ρ = 0.75, p =.01). At follow-up, six patients were taking treatment and were euthymic, we found a negative correlation with the YMRS and RRI at the bilateral orbitofrontal cortex (ρ = −0.8827, p =.019). They did not show significant improvement in cognitive performance at SCIP-S, and there was negative correlation with the following of the SCIP-S subscales; processing speed with the bilateral dorsolateral prefrontal, the bilateral medial prefrontal, the left temporal pole cortex RRI, and verbal fluency with the bilateral anterior cingulate cortex RRI. Conclusion: Cognitive impairment was correlated with brain perfusion patterns at baseline and follow-up. Large sample size studies with longer follow-up are needed to describe the changes in perfusion and cognitive functions in BD.
AB - Background: Patterns of altered cerebral perfusion and cognitive dysfunction have been described in Bipolar Disorder (BD) acute episodes and euthymia. Knowledge of the relationship between cognitive function and perfusion in a manic state and status when followed up is still limited. Objective: To describe brain perfusion alterations and its relationship with cognitive impairment in patients with BD during manic episodes and after 6 months. Methods: Observational-prospective study in 10 type I BD adults during moderate-severe manic episodes. We assessed sociodemographic data and clinical variables as well as cognitive function through Screening for Cognitive Impairment in Psychiatry (SCIP-S). Finally, we performed a Brain Perfusion SPECT using a Tc99m-ethyl cysteine dimer. Results: During manic episodes, patients showed cognitive impairment with a mean SCIP-S score of 63.8 ± 17.16. This was positively correlated with perfusion measured as relative reuptake index (RRI) at the right temporal pole (ρ = 0.65 p =.0435) and negatively correlated with right the orbitofrontal cortex (ρ = −0.70 p =.0077) and the right subgenual cingulate cortex (ρ = −0.70 p =.0256). Episode severity measured by the Young Mania Rating Scale (YMRS) positively correlated with RRI at the right temporal pole (ρ = 0.75, p =.01). At follow-up, six patients were taking treatment and were euthymic, we found a negative correlation with the YMRS and RRI at the bilateral orbitofrontal cortex (ρ = −0.8827, p =.019). They did not show significant improvement in cognitive performance at SCIP-S, and there was negative correlation with the following of the SCIP-S subscales; processing speed with the bilateral dorsolateral prefrontal, the bilateral medial prefrontal, the left temporal pole cortex RRI, and verbal fluency with the bilateral anterior cingulate cortex RRI. Conclusion: Cognitive impairment was correlated with brain perfusion patterns at baseline and follow-up. Large sample size studies with longer follow-up are needed to describe the changes in perfusion and cognitive functions in BD.
KW - bipolar disorder
KW - emission-computed
KW - functional neuroimaging
KW - single-photon
KW - tomography
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U2 - 10.1002/brb3.1615
DO - 10.1002/brb3.1615
M3 - Article
C2 - 32356600
SN - 2157-9032
VL - 10
SP - e01615
JO - Brain and Behavior
JF - Brain and Behavior
IS - 6
M1 - e01615
ER -