Autoimmune encephalitis after BBIBP-CorV (Sinopharm) COVID-19 vaccination: a case report

Miguel A. Vences*, Mary M. Araujo-Chumacero, Edu Cardenas, Diego Canales, Arturo Alvarez, Ebelin Barja, Maria Fe Albujar, Diego Urrunaga-Pastor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Vaccination is an important public health strategy; however, many neurological adverse effects are associated with COVID-19 vaccination, being encephalitis a rare manifestation. Case presentation: We present the case of a 33-year-old woman who received the first dose of the BBIBP-CorV vaccine against COVID-19 on April 4 and the second dose on April 28, 2021. Three days after receiving the second dose, she experienced a subacute episode of headache, fever, insomnia, and transient episodes of environment disconnection. We obtained negative results for infectious, systemic, and oncological causes. Brain magnetic resonance imaging showed lesions in the bilateral caudate nucleus and nonspecific demyelinating lesions at the supratentorial and infratentorial compartments. The results of the neuronal autoantibodies panel were negative. She had an adequate response to immunoglobulin and methylprednisolone; however, she experienced an early clinical relapse and received a new cycle of immunosuppressive treatment followed by a satisfactory clinical evolution. Conclusions: We report the first case of severe encephalitis associated with BBIBP-CorV (Sinopharm) vaccination in Latin America. The patient had atypical imaging patterns, with early clinical relapse and a favorable response to corticosteroid therapy.

Original languageEnglish
Article number427
Pages (from-to)427
JournalBMC Neurology
Issue number1
StatePublished - Dec 2022


  • COVID-19
  • Drug-related side effects and adverse reactions (source: MeSH NLM)
  • Encephalitis
  • Vaccination
  • Recurrence
  • Humans
  • Encephalitis/drug therapy
  • Adult
  • Female
  • COVID-19 Vaccines/adverse effects


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