TY - JOUR
T1 - Atherogenic index of plasma and coronary artery disease
T2 - A systematic review
AU - Ulloque-Badaracco, Juan R.
AU - Hernandez-Bustamante, Enrique A.
AU - Alarcon-Braga, Esteban A.
AU - Mosquera-Rojas, Melany D.
AU - Campos-Aspajo, Alvaro
AU - Salazar-Valdivia, Farley E.
AU - Valdez-Cornejo, Valeria A.
AU - Benites-Zapata, Vicente A.
AU - Herrera-Añazco, Percy
AU - Valenzuela-Rodríguez, Germán
AU - Hernandez, Adrian V.
N1 - Publisher Copyright:
© 2022 the author(s), published by De Gruyter.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Various studies suggest that the atherogenic index of plasma (AIP) is associated with the risk of coronary artery disease (CAD) in different clinical scenarios. This review aimed to synthesize evidence of the association between AIP values and CAD. A literature search was carried out on four databases, namely, PubMed, Scopus, Web of Science, and Ovid-Medline. A handsearch was performed on preprint repositories (MedRxiv and Research Square). The effect measurements were expressed as odds ratios (OR) with their corresponding 95% confidence intervals (CI). For the quantitative synthesis, we employed a random-effects model. We analyzed 14 articles (with 40,902 participants) from seven different countries. The quantitative analysis revealed that an increase in one unit of AIP was associated with higher odds of developing CAD (OR 2.11; 95% CI 1.65-2.69; P < 0.001; I 2 = 98%). We conducted subgroup analyses of Chinese (OR 1.89; 95% CI 1.40-2.56; P < 0.001) and non-Chinese studies (OR 2.51; 95% CI 1.42-4.42; P < 0.001). The sensitivity analysis by risk of bias continued to demonstrate an association, and the heterogeneity remained unchanged (OR 1.75; 95% CI 1.33-2.31; P < 0.001; I 2 = 98%). Higher AIP values were associated with higher odds of developing CAD.
AB - Various studies suggest that the atherogenic index of plasma (AIP) is associated with the risk of coronary artery disease (CAD) in different clinical scenarios. This review aimed to synthesize evidence of the association between AIP values and CAD. A literature search was carried out on four databases, namely, PubMed, Scopus, Web of Science, and Ovid-Medline. A handsearch was performed on preprint repositories (MedRxiv and Research Square). The effect measurements were expressed as odds ratios (OR) with their corresponding 95% confidence intervals (CI). For the quantitative synthesis, we employed a random-effects model. We analyzed 14 articles (with 40,902 participants) from seven different countries. The quantitative analysis revealed that an increase in one unit of AIP was associated with higher odds of developing CAD (OR 2.11; 95% CI 1.65-2.69; P < 0.001; I 2 = 98%). We conducted subgroup analyses of Chinese (OR 1.89; 95% CI 1.40-2.56; P < 0.001) and non-Chinese studies (OR 2.51; 95% CI 1.42-4.42; P < 0.001). The sensitivity analysis by risk of bias continued to demonstrate an association, and the heterogeneity remained unchanged (OR 1.75; 95% CI 1.33-2.31; P < 0.001; I 2 = 98%). Higher AIP values were associated with higher odds of developing CAD.
KW - atherosclerosis
KW - coronary disease
KW - dyslipidemias
KW - heart diseases
KW - lipids
UR - http://www.scopus.com/inward/record.url?scp=85143861108&partnerID=8YFLogxK
U2 - 10.1515/med-2022-0590
DO - 10.1515/med-2022-0590
M3 - Artículo de revisión
AN - SCOPUS:85143861108
SN - 2391-5463
VL - 17
SP - 1915
EP - 1926
JO - Open Medicine (Poland)
JF - Open Medicine (Poland)
IS - 1
ER -
