Asociación entre hipoalbuminemia y toxicidad por quimioterapia en pacientes adultos mayores oncológicos

Valeria Prado; Giuliana Ramos; Ricardo Alor; Laura Cervantes; Carlos D. Neyra-Rivera; Ericson L. Gutiérrez; Fernando M. Runzer-Colmenares; José F. Parodi

Asociación entre hipoalbuminemia y toxicidad por quimioterapia en pacientes adultos mayores oncológicos

Translated title of the contribution: Association between hypoalbuminemia and toxicity by chemotherapy in elderly cancer patients

Valeria Prado, Giuliana Ramos, Ricardo Alor, Laura Cervantes, Carlos D. Neyra-Rivera, Ericson L. Gutiérrez^*, Fernando M. Runzer-Colmenares, José F. Parodi

^*Corresponding author for this work

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Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Introduction: The risk of mortality in elderly patients with cancer and the length of hospital stay are increased due to an albumin concentration lower than 3.5 g/dL. Objective: To determine the association between hypoalbuminemia and chemotherapy toxicity in elderly oncological patients. Methods: Cross-sectional study, conducted in 192 outpatients of Centro Médico Naval del Callao, Perú, males, older than 60 years old. Adverse effects to chemotherapy and associated factors were evaluated between 2013 and 2015. Crude and adjusted Cox regression models were created to determine the association between hypoalbuminemia and the development of chemotherapy toxicity. Results: Association was found between hypoalbuminemia (HR= 1.03; 95% CI: 1.01-1.04), age (HR= 1.02; 95% CI: 1.01-1.04), malnutrition (HR= 1.1; 95% CI: 1.05-1.21), diabetes mellitus (HR= 1.05; 95% CI: 1.00-1.12), body fat percentage (HR= 0.97; 95% CI: 0.92-0.99) and chemotherapy toxicity. Conclusions: In elderly oncology patients at Centro Médico Naval, a significant association is found between hypoalbuminemia and chemotherapy toxicity.

Translated title of the contribution	Association between hypoalbuminemia and toxicity by chemotherapy in elderly cancer patients
Original language	Spanish
Article number	e02202290
Journal	Revista Cubana de Medicina Militar
Volume	51
Issue number	4
State	Published - 1 Oct 2022

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@article{8f729f1de4dc4dde8770c54d23a9df49,

title = "Asociaci{\'o}n entre hipoalbuminemia y toxicidad por quimioterapia en pacientes adultos mayores oncol{\'o}gicos",

abstract = "Introduction: The risk of mortality in elderly patients with cancer and the length of hospital stay are increased due to an albumin concentration lower than 3.5 g/dL. Objective: To determine the association between hypoalbuminemia and chemotherapy toxicity in elderly oncological patients. Methods: Cross-sectional study, conducted in 192 outpatients of Centro M{\'e}dico Naval del Callao, Per{\'u}, males, older than 60 years old. Adverse effects to chemotherapy and associated factors were evaluated between 2013 and 2015. Crude and adjusted Cox regression models were created to determine the association between hypoalbuminemia and the development of chemotherapy toxicity. Results: Association was found between hypoalbuminemia (HR= 1.03; 95% CI: 1.01-1.04), age (HR= 1.02; 95% CI: 1.01-1.04), malnutrition (HR= 1.1; 95% CI: 1.05-1.21), diabetes mellitus (HR= 1.05; 95% CI: 1.00-1.12), body fat percentage (HR= 0.97; 95% CI: 0.92-0.99) and chemotherapy toxicity. Conclusions: In elderly oncology patients at Centro M{\'e}dico Naval, a significant association is found between hypoalbuminemia and chemotherapy toxicity.",

keywords = "dependent elderly, drug – related side effects and adverse drug reactions, elderly, frail elderly, neoplasms",

author = "Valeria Prado and Giuliana Ramos and Ricardo Alor and Laura Cervantes and Neyra-Rivera, {Carlos D.} and Guti{\'e}rrez, {Ericson L.} and Runzer-Colmenares, {Fernando M.} and Parodi, {Jos{\'e} F.}",

year = "2022",

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day = "1",

language = "Espa{\~n}ol",

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journal = "Revista Cubana de Medicina Militar",

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publisher = "Editorial Ciencias Medicas",

number = "4",

}

TY - JOUR

T1 - Asociación entre hipoalbuminemia y toxicidad por quimioterapia en pacientes adultos mayores oncológicos

AU - Prado, Valeria

AU - Ramos, Giuliana

AU - Alor, Ricardo

AU - Cervantes, Laura

AU - Neyra-Rivera, Carlos D.

AU - Gutiérrez, Ericson L.

AU - Runzer-Colmenares, Fernando M.

AU - Parodi, José F.

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Introduction: The risk of mortality in elderly patients with cancer and the length of hospital stay are increased due to an albumin concentration lower than 3.5 g/dL. Objective: To determine the association between hypoalbuminemia and chemotherapy toxicity in elderly oncological patients. Methods: Cross-sectional study, conducted in 192 outpatients of Centro Médico Naval del Callao, Perú, males, older than 60 years old. Adverse effects to chemotherapy and associated factors were evaluated between 2013 and 2015. Crude and adjusted Cox regression models were created to determine the association between hypoalbuminemia and the development of chemotherapy toxicity. Results: Association was found between hypoalbuminemia (HR= 1.03; 95% CI: 1.01-1.04), age (HR= 1.02; 95% CI: 1.01-1.04), malnutrition (HR= 1.1; 95% CI: 1.05-1.21), diabetes mellitus (HR= 1.05; 95% CI: 1.00-1.12), body fat percentage (HR= 0.97; 95% CI: 0.92-0.99) and chemotherapy toxicity. Conclusions: In elderly oncology patients at Centro Médico Naval, a significant association is found between hypoalbuminemia and chemotherapy toxicity.

AB - Introduction: The risk of mortality in elderly patients with cancer and the length of hospital stay are increased due to an albumin concentration lower than 3.5 g/dL. Objective: To determine the association between hypoalbuminemia and chemotherapy toxicity in elderly oncological patients. Methods: Cross-sectional study, conducted in 192 outpatients of Centro Médico Naval del Callao, Perú, males, older than 60 years old. Adverse effects to chemotherapy and associated factors were evaluated between 2013 and 2015. Crude and adjusted Cox regression models were created to determine the association between hypoalbuminemia and the development of chemotherapy toxicity. Results: Association was found between hypoalbuminemia (HR= 1.03; 95% CI: 1.01-1.04), age (HR= 1.02; 95% CI: 1.01-1.04), malnutrition (HR= 1.1; 95% CI: 1.05-1.21), diabetes mellitus (HR= 1.05; 95% CI: 1.00-1.12), body fat percentage (HR= 0.97; 95% CI: 0.92-0.99) and chemotherapy toxicity. Conclusions: In elderly oncology patients at Centro Médico Naval, a significant association is found between hypoalbuminemia and chemotherapy toxicity.

KW - dependent elderly

KW - drug – related side effects and adverse drug reactions

KW - elderly

KW - frail elderly

KW - neoplasms

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M3 - Artículo

AN - SCOPUS:85144042025

SN - 0138-6557

VL - 51

JO - Revista Cubana de Medicina Militar

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M1 - e02202290

ER -

Asociación entre hipoalbuminemia y toxicidad por quimioterapia en pacientes adultos mayores oncológicos

Abstract

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