Anticaries vaccine as a promising alternative for protection against dental caries: A literature review

Sebastian Contreras, Frank Mayta-Tovalino*, Arnaldo Munive-Degregori, Roman Mendoza, John Barja-Ore, Cesar Mauricio-Vilchez

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Aim: The aim of this review was to describe the scientific progress regarding anticaries or dental caries vaccines. Material and Methods: An electronic search without date restriction prioritizing those scientific articles belonging to the last 5 years was performed in the PubMed and Scopus databases. The following keywords were used: 'anticaries vaccine,' 'vaccine against dental caries,' and 'caries vaccine.'Results: A total of 11 studies were considered for the present investigation, of which seven were in vivo, one was in vitro, two were both in vivo and in vitro, and one was a theoretical article. The most frequently investigated parameter was the induction of antigen-specific antibodies generated by the administration of the different types of anticaries vaccines. Conclusions: More in vivo studies aiming at solving the few disadvantages of the current anticaries vaccines need to be carried out to start studies in human samples in the not-too-distant future.

Original languageEnglish
Pages (from-to)34-42
Number of pages9
JournalJournal of International Oral Health
Volume15
Issue number1
DOIs
StatePublished - Jan 2023
Externally publishedYes

Keywords

  • Anticaries
  • Dental Caries
  • Vaccine

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