TY - JOUR
T1 - Alteraciones hematológicas en trabajadores expuestos ocupacionalmente a mezcla de benceno-tolueno-xileno (BTX) en una fábrica de pinturas
AU - Haro-García, Luis
AU - Vélez-Zamora, Nadia
AU - Aguilar-Madrid, Guadalupe
AU - Guerrero-Rivera, Susana
AU - Sánchez-Escalante, Vanessa
AU - Muñoz, Sergio R.
AU - Mezones-Holguín, Edward
AU - Juárez-Pérez, Cuauhtémoc
PY - 2012
Y1 - 2012
N2 - Objectives. Evaluate the three blood cell series and identify the presence of hypochromia, macrocytosis, leucopenia, lymphopenia, and thrombocytopenia in a group of workers exposed to the mixture of benzene-toluene-xylene (BTX). Materials and methods. A cross-sectional study which included 97 workers from a paint factory in Mexico. The participants underwent conventional blood count and tests for potential cumulative daily dose of BTX fumes, to estimate exposure. Results. From the total of workers, 19.6% showed macrocytosis, 18.6%, lymphopenia, hypochromia 10.3%, 7.2% and 5.2% thrombocytopenia leukopenia. The crude association of macrocytosis with exposure to high doses of BTX mixture was the only with statistical significance (OR: 3.6, 95% CI 1.08 to 13.9, P = 0.02), and the base for a logistic regression model (OR: 6.7, 95% CI 1.33 to 13.55, P = 0.02) adjusted for age, alcohol consumption, and smoking. Conclusions. All blood cytological components analyzed demonstrated mild changes, potentially associated with exposure to the mixture of BTX. Macrocytosis could constitute an early manifestation worthy for surveillance.
AB - Objectives. Evaluate the three blood cell series and identify the presence of hypochromia, macrocytosis, leucopenia, lymphopenia, and thrombocytopenia in a group of workers exposed to the mixture of benzene-toluene-xylene (BTX). Materials and methods. A cross-sectional study which included 97 workers from a paint factory in Mexico. The participants underwent conventional blood count and tests for potential cumulative daily dose of BTX fumes, to estimate exposure. Results. From the total of workers, 19.6% showed macrocytosis, 18.6%, lymphopenia, hypochromia 10.3%, 7.2% and 5.2% thrombocytopenia leukopenia. The crude association of macrocytosis with exposure to high doses of BTX mixture was the only with statistical significance (OR: 3.6, 95% CI 1.08 to 13.9, P = 0.02), and the base for a logistic regression model (OR: 6.7, 95% CI 1.33 to 13.55, P = 0.02) adjusted for age, alcohol consumption, and smoking. Conclusions. All blood cytological components analyzed demonstrated mild changes, potentially associated with exposure to the mixture of BTX. Macrocytosis could constitute an early manifestation worthy for surveillance.
KW - Benzene derivatives
KW - Hematologic diseases
KW - Occupational health
KW - Workers
UR - http://www.scopus.com/inward/record.url?scp=84866876754&partnerID=8YFLogxK
U2 - 10.1590/s1726-46342012000200003
DO - 10.1590/s1726-46342012000200003
M3 - Artículo
C2 - 22858763
AN - SCOPUS:84866876754
VL - 29
SP - 181
EP - 187
JO - Revista Peruana de Medicina de Experimental y Salud Publica
JF - Revista Peruana de Medicina de Experimental y Salud Publica
SN - 1726-4634
IS - 2
ER -