A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group

José A. Gómez-Puerta; Guillermo J. Pons-Estel; Rosana Quintana; Romina Nieto; Rosa M. Serrano Morales; Guillermina B. Harvey; Daniel Wojdyla; Marina Scolnik; Carmen Funes Soaje; Paula Alba Moreyra; Elisa Novatti; Fernando Arizpe; Guillermo A. Berbotto; Luciana González Lucero; Sabrina Porta; Nicolás Pérez; Anabella M. Rodriguez; Simone Appenzeller; Ana Carolina de Oliveira e Silva Montadon; Odirlei Andre Monticielo; Fernando S. Cavalcanti; Francinne Machado Ribeiro; Eduardo F. Borba; Edgard Torres dos Reis-Neto; Oscar Neira; José Miguel Chahuán; Milena Mimica; Gustavo Aroca Martínez; Gabriel J. Tobón; Gloria Vásquez; Gerardo Quintana-Lopez; Mario J. Moreno Alvarez; Miguel Ángel Saavedra; Mario Pérez Cristobal; Hilda Fragoso-Loyo; Luis M. Amezcua-Guerra; Yelitza C. González-Bello; Carlos Abud-Mendoza; Jorge A. Esquivel-Valerio; Margarita Duarte; Isabel Acosta Colman; Claudia Mora-Trujillo; Cristina Reátegui-Sokolova; Armando A. Calvo Quiroz; Roberto Muñoz-Louis; Ernesto Cairoli; Iliana Rosas; Martín Rebella; Mario H. Cardiel; Ignacio García de la Torre; Luis J. Catoggio; Graciela S. Alarcón; Bernardo A. Pons-Estel

doi:10.1177/0961203320988586

A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group

José A. Gómez-Puerta, Guillermo J. Pons-Estel, Rosana Quintana, Romina Nieto, Rosa M. Serrano Morales, Guillermina B. Harvey, Daniel Wojdyla, Marina Scolnik, Carmen Funes Soaje, Paula Alba Moreyra, Elisa Novatti, Fernando Arizpe, Guillermo A. Berbotto, Luciana González Lucero, Sabrina Porta, Nicolás Pérez, Anabella M. Rodriguez, Simone Appenzeller, Ana Carolina de Oliveira e Silva Montadon, Odirlei Andre MonticieloFernando S. Cavalcanti, Francinne Machado Ribeiro, Eduardo F. Borba, Edgard Torres dos Reis-Neto, Oscar Neira, José Miguel Chahuán, Milena Mimica, Gustavo Aroca Martínez, Gabriel J. Tobón, Gloria Vásquez, Gerardo Quintana-Lopez, Mario J. Moreno Alvarez, Miguel Ángel Saavedra, Mario Pérez Cristobal, Hilda Fragoso-Loyo, Luis M. Amezcua-Guerra, Yelitza C. González-Bello, Carlos Abud-Mendoza, Jorge A. Esquivel-Valerio, Margarita Duarte, Isabel Acosta Colman, Claudia Mora-Trujillo, Cristina Reátegui-Sokolova, Armando A. Calvo Quiroz, Roberto Muñoz-Louis, Ernesto Cairoli, Iliana Rosas, Martín Rebella, Mario H. Cardiel, Ignacio García de la Torre, Luis J. Catoggio, Graciela S. Alarcón, Bernardo A. Pons-Estel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.

Original language	English
Pages (from-to)	961203320988586
Journal	Lupus
DOIs	https://doi.org/10.1177/0961203320988586
State	Published - 2021
Externally published	Yes

Keywords

Latin American
Lupus
biomarkers
lupus nephritis
multiethnic

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10.1177/0961203320988586

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Gómez-Puerta, J. A., Pons-Estel, G. J., Quintana, R., Nieto, R., Serrano Morales, R. M., Harvey, G. B., Wojdyla, D., Scolnik, M., Funes Soaje, C., Alba Moreyra, P., Novatti, E., Arizpe, F., Berbotto, G. A., González Lucero, L., Porta, S., Pérez, N., Rodriguez, A. M., Appenzeller, S., de Oliveira e Silva Montadon, A. C., ... Pons-Estel, B. A. (2021). A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group. Lupus, 961203320988586. https://doi.org/10.1177/0961203320988586

@article{36b2bbad42c94ee7af869aaf2dce119c,

title = "A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group",

abstract = "Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.",

keywords = "Latin American, Lupus, biomarkers, lupus nephritis, multiethnic",

author = "G{\'o}mez-Puerta, {Jos{\'e} A.} and Pons-Estel, {Guillermo J.} and Rosana Quintana and Romina Nieto and {Serrano Morales}, {Rosa M.} and Harvey, {Guillermina B.} and Daniel Wojdyla and Marina Scolnik and {Funes Soaje}, Carmen and {Alba Moreyra}, Paula and Elisa Novatti and Fernando Arizpe and Berbotto, {Guillermo A.} and {Gonz{\'a}lez Lucero}, Luciana and Sabrina Porta and Nicol{\'a}s P{\'e}rez and Rodriguez, {Anabella M.} and Simone Appenzeller and {de Oliveira e Silva Montadon}, {Ana Carolina} and Monticielo, {Odirlei Andre} and Cavalcanti, {Fernando S.} and {Machado Ribeiro}, Francinne and Borba, {Eduardo F.} and {Torres dos Reis-Neto}, Edgard and Oscar Neira and Chahu{\'a}n, {Jos{\'e} Miguel} and Milena Mimica and {Aroca Mart{\'i}nez}, Gustavo and Tob{\'o}n, {Gabriel J.} and Gloria V{\'a}squez and Gerardo Quintana-Lopez and {Moreno Alvarez}, {Mario J.} and Saavedra, {Miguel {\'A}ngel} and Cristobal, {Mario P{\'e}rez} and Hilda Fragoso-Loyo and Amezcua-Guerra, {Luis M.} and Gonz{\'a}lez-Bello, {Yelitza C.} and Carlos Abud-Mendoza and Esquivel-Valerio, {Jorge A.} and Margarita Duarte and {Acosta Colman}, Isabel and Claudia Mora-Trujillo and Cristina Re{\'a}tegui-Sokolova and {Calvo Quiroz}, {Armando A.} and Roberto Mu{\~n}oz-Louis and Ernesto Cairoli and Iliana Rosas and Mart{\'i}n Rebella and Cardiel, {Mario H.} and {Garc{\'i}a de la Torre}, Ignacio and Catoggio, {Luis J.} and Alarc{\'o}n, {Graciela S.} and Pons-Estel, {Bernardo A.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021.",

year = "2021",

doi = "10.1177/0961203320988586",

language = "Ingl{\'e}s",

pages = "961203320988586",

journal = "Lupus",

issn = "0961-2033",

publisher = "SAGE Publications Ltd",

}

Gómez-Puerta, JA, Pons-Estel, GJ, Quintana, R, Nieto, R, Serrano Morales, RM, Harvey, GB, Wojdyla, D, Scolnik, M, Funes Soaje, C, Alba Moreyra, P, Novatti, E, Arizpe, F, Berbotto, GA, González Lucero, L, Porta, S, Pérez, N, Rodriguez, AM, Appenzeller, S, de Oliveira e Silva Montadon, AC, Monticielo, OA, Cavalcanti, FS, Machado Ribeiro, F, Borba, EF, Torres dos Reis-Neto, E, Neira, O, Chahuán, JM, Mimica, M, Aroca Martínez, G, Tobón, GJ, Vásquez, G, Quintana-Lopez, G, Moreno Alvarez, MJ, Saavedra, MÁ, Cristobal, MP, Fragoso-Loyo, H, Amezcua-Guerra, LM, González-Bello, YC, Abud-Mendoza, C, Esquivel-Valerio, JA, Duarte, M, Acosta Colman, I, Mora-Trujillo, C, Reátegui-Sokolova, C, Calvo Quiroz, AA, Muñoz-Louis, R, Cairoli, E, Rosas, I, Rebella, M, Cardiel, MH, García de la Torre, I, Catoggio, LJ, Alarcón, GS & Pons-Estel, BA 2021, 'A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group', Lupus, pp. 961203320988586. https://doi.org/10.1177/0961203320988586

TY - JOUR

T1 - A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus

T2 - Launching the GLADEL 2.0 Study Group

AU - Gómez-Puerta, José A.

AU - Pons-Estel, Guillermo J.

AU - Quintana, Rosana

AU - Nieto, Romina

AU - Serrano Morales, Rosa M.

AU - Harvey, Guillermina B.

AU - Wojdyla, Daniel

AU - Scolnik, Marina

AU - Funes Soaje, Carmen

AU - Alba Moreyra, Paula

AU - Novatti, Elisa

AU - Arizpe, Fernando

AU - Berbotto, Guillermo A.

AU - González Lucero, Luciana

AU - Porta, Sabrina

AU - Pérez, Nicolás

AU - Rodriguez, Anabella M.

AU - Appenzeller, Simone

AU - de Oliveira e Silva Montadon, Ana Carolina

AU - Monticielo, Odirlei Andre

AU - Cavalcanti, Fernando S.

AU - Machado Ribeiro, Francinne

AU - Borba, Eduardo F.

AU - Torres dos Reis-Neto, Edgard

AU - Neira, Oscar

AU - Chahuán, José Miguel

AU - Mimica, Milena

AU - Aroca Martínez, Gustavo

AU - Tobón, Gabriel J.

AU - Vásquez, Gloria

AU - Quintana-Lopez, Gerardo

AU - Moreno Alvarez, Mario J.

AU - Saavedra, Miguel Ángel

AU - Cristobal, Mario Pérez

AU - Fragoso-Loyo, Hilda

AU - Amezcua-Guerra, Luis M.

AU - González-Bello, Yelitza C.

AU - Abud-Mendoza, Carlos

AU - Esquivel-Valerio, Jorge A.

AU - Duarte, Margarita

AU - Acosta Colman, Isabel

AU - Mora-Trujillo, Claudia

AU - Reátegui-Sokolova, Cristina

AU - Calvo Quiroz, Armando A.

AU - Muñoz-Louis, Roberto

AU - Cairoli, Ernesto

AU - Rosas, Iliana

AU - Rebella, Martín

AU - Cardiel, Mario H.

AU - García de la Torre, Ignacio

AU - Catoggio, Luis J.

AU - Alarcón, Graciela S.

AU - Pons-Estel, Bernardo A.

PY - 2021

Y1 - 2021

N2 - Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.

AB - Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.

KW - Latin American

KW - Lupus

KW - biomarkers

KW - lupus nephritis

KW - multiethnic

UR - http://www.scopus.com/inward/record.url?scp=85100631536&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/8ba257c9-8ec4-38a5-ac2c-fcfeceb469b3/

U2 - 10.1177/0961203320988586

DO - 10.1177/0961203320988586

M3 - Artículo

C2 - 33509067

AN - SCOPUS:85100631536

SN - 0961-2033

SP - 961203320988586

JO - Lupus

JF - Lupus

ER -

A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group

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