A Functional Assessment Tool to Distinguish Controls From Alzheimer’s Disease in Lima, Peru

Nilton Custodio, Rosa Montesinos, Diego Chambergo-Michilot, Eder Herrera-Perez, Maritza Pintado-Caipa, Wendy Seminario G, José Cuenca, Laura Mesía, Virgilio E. Failoc-Rojas, Monica M. Diaz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer’s disease (ad). We evaluated its performance in controls, Peruvians with MCI or AD. Methods: A cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), ad or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach’s alpha) and validity were assessed. Results: We enrolled 276 individuals (ad: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC:.996), and Cronbach’s alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate ad severity. The ADCS-ADL correlated highly with nearly all tools. Conclusions: The ADCS-ADL scale is reliable in a population with ad in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.

Original languageEnglish
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume37
DOIs
StatePublished - May 2022

Keywords

  • alzheimer disease
  • dementia
  • neurocognitive disorders
  • peru
  • validation study

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